Hippo regulates cell division
نویسندگان
چکیده
منابع مشابه
The Hippo Pathway Core Cassette Regulates Asymmetric Cell Division
Asymmetric cell division (ACD) is a crucial process during development, homeostasis, and cancer. Stem and progenitor cells divide asymmetrically, giving rise to two daughter cells, one of which retains the parent cell self-renewal capacity, while the other is committed to differentiation. Any imbalance in this process can induce overgrowth or even a cancer-like state. Here, we show that core co...
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Identification of the signaling pathways that control the proliferation of stem cells (SCs), and whether they act in a cell or non-cell autonomous manner, is key to our understanding of tissue homeostasis and cancer. In the adult Drosophila midgut, the Jun N-Terminal Kinase (JNK) pathway is activated in damaged enterocyte cells (ECs) following injury. This leads to the production of Upd cytokin...
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Hippo pathway controls the organ size by modulating cell proliferation and apoptosis. However, the upstream regulation of hippo signaling by actin cytoskeleton is not clear. To elucidate the role of actin as an upstream regulator of Hippo signaling, the levels of F (filamentous)-actin in cells were elevated using jasplakinolide, an actin-stabilizing drug. Induction of F-actin formation in HeLa ...
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13 14 The Hippo pathway controls tissue growth through a core kinase cascade that impinges on the 15 transcription of growth-regulatory genes. Understanding how this pathway is regulated in 16 development remains a major challenge. Recent studies suggested that Hippo signaling can be 17 modulated by cytoskeletal tension through a Rok-myosin II pathway. How cytoskeletal tension is 18 regulated o...
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ژورنال
عنوان ژورنال: Nature Reviews Molecular Cell Biology
سال: 2015
ISSN: 1471-0072,1471-0080
DOI: 10.1038/nrm4089